Thesis Title: Development and evaluation of an orthopedic absorbable implant based on chitosan
PhD Supervisors: Alexandra Rodrigues (ISEL/IST-UL), Frederico Ferreira (IST-UL), Luís Pinto (Altakitin S.A.)
Thesis Abstract: The main medical applications of chitosan-based products include wound dressing sutures and tissue engineering scaffolds. However, the application of chitosan and its derivatives in 3D forms is very limited due to the inherent difficulties of the development process. The aim of this work is to produce and characterize 3D dense pieces based on chitosan to be used as (internal) bioabsorbable fixation devices. These products require the right strength and stiffness, which are necessary to allow the movement and comfort of the patient until the biological tissue is reconstructed. Additionally, they must be biocompatible, induce the bone formation and degrade over time. In this sense, experimental research work related with the optimization of the manufacturing process of the 3D chitosan pieces will be performed, involving its mechanical, microstructural and biological characterization.