André Fialho

andre.fialho.jpgThis email address is being protected from spambots. You need JavaScript enabled to view it. | IST | Bioengineering PhD | Entering year: 2008

PhD Supervisor: João Sousa (IST), Stan Neil Finkelstein (MIT) 

PhD Thesis (2012): Knowledge Discovery in Intensive Care Unit Shock Patients 

Andre's PhD work address a common clinical issue between patients in an intensive care unit (ICU) – Shock – by determining the extent to which variations in the processes of care influence outcome. By using a variety of advanced data mining/analytic techniques, the two main goals of his work includes the establishment of a robust quantitative basis for systems-based interventions to improve outcomes in the ICU shock patients; and the development of a reproducible framework for applying the data mining strategies to other healthcare venues.

António Soure

António SoureThis email address is being protected from spambots. You need JavaScript enabled to view it. | IST | Bioengineering Systems PhD | Entering year: 2012 | Graduation year: 2017

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Thesis Title: “Scalable Manufacturing of Mesenchymal Stem/Stromal Cells for Cell Therapies and the Role of the Notch Signaling Pathway in the Human Hematopoietic Systems”.

Supervisors: Joaquim Sampaio Cabral (IST-UL) and Cláudia Lobato da Silva (IST-UL).

Thesis Abstract: My research focuses on the expansion/selection of regulatory T-cells, using a mesenchymal stem cell (MSC)-based co-culture system. Briefly, MSC are obtained from differente sources (bone marrow and adipose tissue) and cultured in vitro until confluent. Peripheral blood mononuclear cells (PBMC) or purified regulatory T-cells (Treg) are also added to examine the ability of MSC to induce and expand Treg in vitro. To determine if the mechanism by which MSC induce/expand Treg is due to cell-cell contact or the release of soluble factors, transwell experiments are performed and blocking antibodies against relevant soluble factors (e.g. IL-2, IL-10, TGF-β, IL-17) are used. Also, I have been studying the influence of a serum-free medium, containing human platelet lysate, in the expansion and immunomodulatory properties of adipose tissue and umbical-cord matrix-derived MSC.

António Vicente

António Vicente BioThis email address is being protected from spambots. You need JavaScript enabled to view it. | FCTUNL | Bioengineering PhD | Entering year: 2008 | Graduation year: 2015

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Current position: Research Member at CENIMAT/CEMOP

Thesis Title: Development of nanomorphous silicon solar cells on ceramic substrates with biomedical application

Supervisors: Rodrigo Martins (FCT-UNL); Hugo Águas (FCT-UNL)

Bárbara Cunha

fBárbara Cunha This email address is being protected from spambots. You need JavaScript enabled to view it. | FCTUNL | Bioengineering Systems PhD | Entering year: 2012 | Graduation year: 2016

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Current Position: Senior Scientist: Cell & Gene Therapy Downstream Process Development at GlaxoSmithKline

Thesis Title: Development of integrated strategies for the downstream processing of human stem cells for clinical application

Supervisors: Margarida Serra (iBET/ITQB-UNL), Paula Alves (iBET/ITQB-UNL)

Research Summary: The aim of this PhD project was to establish scalable and integrated downstream processing (DSP) strategies, based on filtration technologies, for the clarification, concentration and washing unit operations for adult and pluripotent SC from human origin without compromising cells’ quality. Human mesenchymal stem cells (hMSC) and human induced pluripotent stem cells (hiPSC) will be used as challenging and complex cell-based products. A systematic approach will be developed by combining membrane technology and chromatographic tools in a robust, scalable, compatible with current good manufacturing practices (c-GMP), and affordable process, aiming at establishing a flexible platform, which can be transferred to clinical/industrial settings. This research as won an award for “best student poster prize” in the 2015 conference “Scale-up and Manufacturing of Cell-Based Therapies IV” in San Diego, California.

Carla Moura

Carla MouraThis email address is being protected from spambots. You need JavaScript enabled to view it. | IST | Bioengineering Systems PhD | Entering year: 2010 | Graduation year: 2016

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Current Position: Researcher at 6he Centre for Rapid and Sustainable Product Development (CDRsp), Polytechnic Institute of Leiria

Thesis Title: Development of hydrogel-based constructs with encapsulated cells

Supervisors: Frederico Ferreira (IST-UL), Paulo Bartolo (IPL)