Ana Sofia Araújo Ferreira

This email address is being protected from spambots. You need JavaScript enabled to view it. | UMinho | Bioengineering Systems PhD | Entering year: 2013/2014 

Research area: Bioengineering, Biotechnology and Biochemistry

Supervisor: Isabel Rocha (CEB-University of Minho)

Thesis topic:The growing global demand for new energy sources combined with environmental concerns had motivated the search for alternative fuels, produced from renewable raw materials. In this sense, butanol is considered the next generation of biofuels due to its superior fuel characteristics when compared with ethanol, including higher energy density, lower hygroscopicity and volatility. Besides its application as fuel, butanol has an important role in the manufacturing of pharmaceuticals, polymers, herbicide esters and butyl xanthate, and is also used as solvent for paints, coatings, natural resins, gums, synthetic resins, dyes, and alkaloids.

Butanol is naturally produced by solventogenic bacteria trough Acetone-Butanol-Ethanol (ABE) fermentation, usually with low productivities. Thus, most of butanol is currently chemical synthesised via petrochemical routes and its price is extremely sensitive to crude oil’s price, becoming imperative to seek for alternative ways to produce it. One possible approach is to express novel biosynthetic pathways in more user-friendly hosts as E. coli or Saccharomyces cerevisiae. In this sense, this work aims at evaluating and implementing in vivo novel pathways to produce butanol. These heterologous pathways, previously generated using a (hyper)graph-based algorithm, will be evaluated according to diverse criteria such as size of the solution, yield and novelty. Then, the pathways identified as the most promising ones will be implemented in vivo either in E. coli or S. cerevisiae. Finally, advanced techniques will be used to characterize and further improve the developed strains, including omics analyses and directed evolution.

Andreia Filipa Relvas Pimenta

This email address is being protected from spambots. You need JavaScript enabled to view it. | IST | Bioengineering Systems PhD | Entering year: 2012/2013

Research area: Bioengineering

PhD Supervisor: Rogério Colaço (Instituto Superior Técnico - Universidade de Lisboa)

Thesis Topic: The main aim of the work plan is to develop and optimize surface modified/coated drug-releasing hydrogels to be used in therapeutic ophthalmic lenses. For that, different surface coating/modification strategies will be tested in order to create drug diffusion barriers, which lead to a continuous and gradual dispense of medication to the eye, at adjustable rates, and for extended periods. The drug release kinetics of antibiotics and an anti-glaucoma beta-blockers will be investigated through in vitro tests by using an equipment specially conceived to simulate the eye function, which allows a reliable extrapolation to the biological conditions. Appropriate physical-chemical and biological experimentation will be performed in view of future (pre)clinical validation.

Carlos Boto

carlos.botoThis email address is being protected from spambots. You need JavaScript enabled to view it. | FCTUNL | Bioengineering PhD | Entering year: 2009

pdf CV Carlos Boto

Catarina Araújo Gomes Rebelo

This email address is being protected from spambots. You need JavaScript enabled to view it. | UCoimbra | Bioengineering Systems PhD | Entering year: 2013/2014

Research area: Cell and tissue engineering

PhD Supervisor:  Lino Ferreira (CNC, UC)

Thesis Topic: During this PhD we will develop a cell-free therapy for myocardial infarction treatment that explores the endogenous modulation of CSCs. We aim at enhancing this intrinsic self-repair mechanism that exists in the mammalian heart. To accomplish this objective, we will use an innovative platform based on opto-nanomedicine for the remote delivery of biomolecules. The main objective of the project is to evaluate the regenerative potential of biomolecules released into the heart after light activation.

César Costa

cesar.costaThis email address is being protected from spambots. You need JavaScript enabled to view it. | UMinho | Bioengineering Systems PhD | Entering year: 2012

pdf CV César Costa

Research topic/area: Nanotechnologies applied to the treatment of tuberculosis: Development of strategies for antimicrobial peptides delivery to infected macrophages

Research Summary: Drug delivery systems and Drug development; Protein engineering; Glycobiology; Molecular pharming.

Personal webpage

David Botequim

david.botequimThis email address is being protected from spambots. You need JavaScript enabled to view it. | UMinho | Bioengineering Systems PhD | Entering year: 2012

pdf CV David Botequim

Research topic/area: Osteoconductive and biomimetic composite materials containing new bioactive nanoparticles for orthopaedic applications

Research Summary: Electrospinning and nanofibers; antimicrobial materials and surfaces; nanoparticles for orthopaedic applications.

Publications: Botequim D., Maia J., Lino M., Simões P., Ilharco L., Ferreira L., “Nanoparticles and surfaces presenting antifungal, antibacterial and antiviral properties”, Langmuir, 28 (20), pp 7647-7656 (2012), DOI: 10.1021/la300948n.

Henriques C., Vidinha R., Botequim D., Borges J. P., Silva J. A. M. C., “A systematic study of solution and processing parameters on nanofibre morphology using a new electrospinning apparatus”, Journal of Nanoscience and Nanotechnology 9, 3535-3545 (2009), DOI: 10.1166/jnn.2009.NS27.

Diogo de Sousa Pinto

This email address is being protected from spambots. You need JavaScript enabled to view it. | IST | Bioengineering Systems PhD | Entering year: 2013/2014

PhD Supervisor: Joaquim Sampaio Cabral - Instituto Superior Técnico

Thesis Topic: Development of a cell-based product with enhanced therapeutic features for myocardial regeneration through an integrative bioprocess approach

Gianluca Selvaggio

Gianluca SelvaggioThis email address is being protected from spambots. You need JavaScript enabled to view it. | FCTUC | Bioengineering System PhD | Entering year: 2011

Research topic/area:Seeking general principles in the design of defense systems against hydrogen peroxide

pdf CV Gianluca Selvaggio

Hélder Moisés Gonçalves Pinheiro Lopes

This email address is being protected from spambots. You need JavaScript enabled to view it. | UMinho | Bioengineering Systems PhD | Entering year: 2013/2014

Research area: Systems Biology, Metabolic Engineering.

PhD Supervisor: Isabel Rocha, CEB-Universidade do Minho

Thesis Topic: Accelerating metabolic engineering tasks by the in silico development of yeast cell factories Abstract: Saccharomyces cerevisiae is one of the most widely used cell factories in industrial biotechnology. However, the development of optimized yeast strains for the production of novel compounds is a time-consuming process and represents a significant cost and time burden. Key underlying reasons include the unavailability of suitable chassis cells and lack of proven modelling tools. This PhD proposal aims at contributing towards overcoming these limitations by using cutting-edge computational and experimental tools. These will be applied to improved production of polyketides and other industrially relevant compounds that originate from the same precursors.

In the first stage, we intend to complement the available metabolic models with phenotype information from Saccharomyces Genome Database (SGD), using a systematic analysis approach. Afterwards, the improved model will be used to identify targets for gene deletion or overexpression towards overproduction of compounds originating from the same building blocks, namely acetyl-CoA and malonyl-coA.

Experimental validation of the optimized predictions will be performed by constructing high-producer yeast strains for production of the model polyketide 6-methylsalicylic acid.

Henrique F. Carvalho

henrique.f.carvalhoThis email address is being protected from spambots. You need JavaScript enabled to view it. | FCTUNL | Bioengineering Systems PhD | Entering year: 2012

pdf CV Henrique F. Carvalho

Research topic/area: Developing Artificial Zinc Fingers with Peptidase Activity

Research Summary: The overall goal is to redesign the zinc domain of the zinc finger proteins to obtain stable peptidic scaffolds capable of coordinating transition metal ions and displaying peptidase activity. Development of recyclable catalysts will also be pursued by attaching the best candidates to solid supports and test their catalytic activity.

Inês Agapito Honório

Ines HonorioThis email address is being protected from spambots. You need JavaScript enabled to view it. | Biocant/CNC | Bioengineering Systems PhD | Entering year: 2011

Research topic/area: Cell and Tissue Engineering. Bioengineering. Nanobiotechnology and Biomaterials. Stem Cells and human pluripotent stem cells Cells.

pdf CV Inês Honório

Isa Monteiro

isa.monteiro.jpgThis email address is being protected from spambots. You need JavaScript enabled to view it. | UMinho | Bioengineering PhD | Entering year: 2007

pdfCV Isa Monteiro

Research topic/area: Regenerative Medicine / Tissue Engineering

Research interests: Stem cells differentiation, biomaterials for Tissue Engineering.

Other interests: Innovation, Clinical Economics.

Links:

http://www.3bs.uminho.pt/

http://www.ibb.pt/

João Arrais

joao.arrais.jpgThis email address is being protected from spambots. You need JavaScript enabled to view it. | IST | Bioengineering PhD | Entering year: 2008

Maria João Carvalho Sebastião

 This email address is being protected from spambots. You need JavaScript enabled to view it. | IST | Bioengineering Systems PhD | Entering year: 2013/2014

Research topic/area: Towards novels stem cell-based therapies for myocardium regeneration

Miguel Amador

Miguel AmadorThis email address is being protected from spambots. You need JavaScript enabled to view it. | IST | Bioengineering Systems PhD | Entering year: 2012

pdfCV Miguel Amador

Research topic/ area: Research on risk governance with a direct application to science, technology and public policy: development of new regulatory frameworks on Regenerative Medicine.

Research summary: The purpose of my work is to support a deep study of the transitional process from scientific research to clinical research regarding cell therapies technology. Studying ongoing research and clinical trials, the objective is to understand how regulation shape practices, and establish barriers in the move to the clinical usage. Understanding the impacts of public policies through legal and regulatory frameworks in the development of such breakthrough treatments, that challenges our scientific knowledge, and common medicinal practices, is a requirement to adapt it, in the ultimate goal of fostering public health.

Patricia Pitrez Pereira

particia-pitrezThis email address is being protected from spambots. You need JavaScript enabled to view it. | UMinho | Bioengineering Systems PhD | Entering year: 2010

pdf CV Patricia Pitrez

Research topic/area: Development of a tissue engineered intestine

Research Summary:
A number of gut disorders, including Crohn’s disease, can lead to Short Bowel Syndrome (SBS). SBS compromises (i) the nutrient transport function of the mucosa layer and (ii) the peristalsis function of the muscularis propria layer. A potential treatment for SBS would be the development of a living, tissue engineered small intestinal graft to replace the lost tissue. Several attempts have been made to tissue engineer small intestine; however, they fail to reproduce the complexity and functionality of living tissue. The general aim of this work is to develop a tissue engineered intestine.

Pawel Bujalski

This email address is being protected from spambots. You need JavaScript enabled to view it. | IST | Bioengineering Systems PhD | Entering year: 2013/2014

Research area: Biomechanics, Intelligent Systems

PhD Supervisor: Jorge Martins (IST) ; Dava Newman  (MIT)

Thesis Topic: Impedance Shaping and Inertial Sensing for the design and control of hybrid Human-Machine system.The broad aim of this research project is to explore new designs of robotic devices for physical rehabilitation and augmentation of humans. Under the hypotheses that impedance shaping, achieved through a control network of muscle actuation and proprioceptive sensing, regulates human motion, the proposed research targets the following key points: To devise and implement human performance experiments in order to uncover and model the biological impedance variation methods adopted during different tasks in locomotion and manipulation.

  1. To devise bio-inspired sensing estimation and control algorithms for impedance shaping.
  2. To explore the embodiment of the developed algorithms in compliant exoskeletons, as well as in functional electrical stimulation.

This research follows and builds on previous work developed at IST, in the development of hybrid active orthotics for the ankle joint, and on the research performed at MIT leading to the development of the BioSuit – a second skin compliant counter pressure suit for space exploration.

Pedro Gouveia

no-photoThis email address is being protected from spambots. You need JavaScript enabled to view it. | FCTUNL | Bioengineering PhD | Entering year: 2009

Pedro Miguel Macedo Geada

This email address is being protected from spambots. You need JavaScript enabled to view it. | UMinho | Bioengineering Systems PhD | Entering year: 2013/2014

Research area: Bioengineering

PhD Supervisor: Bruno Fernandes (Centre of Biological Engineering, University of Minho);  António Vicente (Centre of Biological Engineering, University of Minho); Vítor Vasconcelos (Interdisciplinary Centre of Marine and Environmental Research, University of Porto)

Thesis Topic: Development and optimization of cultivation systems and techniques in order to improve cyanotoxin productivity and cost effectivenes. Worldwide occurrence of hepatotoxic cyanobacteria and their toxins pose serious threats to public health. However, cyanotoxins can be used as laboratory standards in human and environmental risk assessment or even as tools for molecular and cell biology studies. Presently, their availability is low due to difficulties found in production and purification processes, which influence the final price. On the other hand, the variation of cyanobacterial blooms toxicity is probably due to environmental factors. Thus, the study of the influence of environmental factors on cyanobacteria growth and toxicity might help to control them just by monitoring environmental factors. The aim of this project is to evaluate the influence of environmental conditions (temperature, etc.) in cyanobacteria growth and toxin production. Cyanotoxin extraction and purification methods will also be developed.

Raquel Almeida

This email address is being protected from spambots. You need JavaScript enabled to view it.Raquel Almeida | UMinho | Bioengineering Systems PhD | Entering year: 2013

Research Area: Stem Cell, Tissue Engineering and Regenerative Medicine

Supervisor: Manuela E. Gomes (3B's Research Group, Universidade do Minho)

Thesis Title: Biomimetic microengineered hydrogels for tendon tissue engineering

Research Summary: Musculoskeletal diseases are one of the leading causes of disability worldwide. Among them, tendon injuries are responsible for substantial morbidity, pain and disability, affecting athletes, active working people, and elder population whose joint movements rely on the biomechanical interplay of intrinsic and extrinsic musculotendinous forces.

Raquel Medina dos Santos Cunha

This email address is being protected from spambots. You need JavaScript enabled to view it. | IST | Bioengineering Systems PhD | Entering year: 2013/2014

Research area: Stem cell research

Thesis topic: Development of clinical grade stem cell-based products with enhanced therapeutic potential for cardiac regeneration

PhD Supervisors: Cláudia Lobato da Silva, Instituto Superior Técnico and MD. António Fiarresga, Centro Hospitalar de Lisboa Central, Hospital de Santa Marta

Siddhi Bianca Camila Lama

This email address is being protected from spambots. You need JavaScript enabled to view it. | IST | Bioengineering Systems PhD | Entering year: 2013/2014

PhD Supervisor: Frederico Ferreira (IST)

Thesis Topic: Bioengineering skin-mechanoreceptor sensing to enhance function in hybrid human machine interface systems.Throughout human existence, limb loss has been considered an irreversible detriment and permanent loss of sensory function. Prosthetics have attempted to act as replacements for lost limbs and digits for thousands of years. Until the 19th century, they were mainly passive, cosmetic devices, giving the user minimal sensory feedback and acting as little more than hooks. Today, there are various ongoing clinical trials related to surgical attachment of prosthetics utilizing osseointegration and incorporation of implantable electrodes. This, alongside the simultaneous design of lightweight, integrated prosthetics, has led to revolutionary breakthroughs with sensory feedback, control, and range of motion for amputees. Despite these breakthroughs, however, prosthetics remain years away from successfully mimicking a complete motor and somatosensory function. Lack of innervated skin, which allows for a myriad of tactile stimuli to be detected and interpreted, is perhaps the greatest hindrance in giving amputees complete sensory feedback. This too has been combated through design of artificial skin substitutes, enabling users with increased --but not standard-- sensory feedback. Finally, novel advances in composite tissue surgeries have enabled complete limb transplantation. However, as with other transplantations, psychological assessment and lifelong immunosuppressants are mandatory, making this technique unsuitable for everyone. This project focuses on analysis of skin-mechanoreceptor sensing in order to understand aspects of somatosensory function that are difficult to replicate in artificial limb replacement, as well as fully regain through transplantation. Successful bioengineering of the somatosensory system can be integrated into the novel, bi-directional human-machine interface, leading to enhanced sensory function.

Tânia Mendes

tania.mendesThis email address is being protected from spambots. You need JavaScript enabled to view it. | FCTUNL | Bioengineering Systems PhD | Entering year: 2012

pdf CV Tania Mendes

Research topic/area: Biotechnology